Mew is a MIME mail reader of Emacs. It can handle multi mailboxes and collabrates with other programs well. This is my configuration of mew.

NOTE:

1. I used Stunnel for SSL connection. You must modify the file location of Stunnel. If you use Mac OS X, you can install it using DarwinPorts as I do.
2. If you want to use BBDB with Mew, take a look at Chris Beggy’s setup (it’s old, but it works).
3. My resources for the setup are here (Chinese), here, and here.

UPDATE #2: I created a .mew.el files list.